insulin resistance
Type: condition- Systems Analogy A worn-out receptor terminal keyhole that requires multiple duplicate key signals to trigger the gate open.
- Formal Definition A physiological condition where cells fail to respond effectively to the hormone insulin, impairing glucose uptake and forcing the pancreas to overproduce insulin to maintain normal blood glucose levels.
Mentioned In
- Biological CircuitsDHA Target Engagement & Cognition in Dementia Risk
- Lifestyle PracticesCGM Non-Diabetic Glycotypes & Dysregulation
- Conditionmetabolic syndrome
Scientific Sources & Literature Citations
- [1] Empirical Study Reaven GM. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-1607. ↗
"Insulin resistance is a fundamental defect in non-insulin-dependent diabetes mellitus and plays a central role in metabolic syndrome pathogenesis."