insulin resistance
Type: condition Systems Analogy
A worn-out receptor terminal keyhole that requires multiple duplicate key signals to trigger the gate open.
A physiological condition where cells fail to respond effectively to the hormone insulin, impairing glucose uptake and forcing the pancreas to overproduce insulin to maintain normal blood glucose levels.
Mentioned In
Scientific Sources & Verbatim Definitions
- Empirical StudyReaven GM. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-1607. ↗
"Insulin resistance is a fundamental defect in non-insulin-dependent diabetes mellitus and plays a central role in metabolic syndrome pathogenesis."