neuroinflammation

Aliases: brain inflammation inflammatory cascades in the brain neuroinflammation markers

Systems Analogy

A citywide emergency siren and hazmat deployment that blocks major thoroughfares and damages storefronts while hunting down a minor disturbance.

An inflammatory response within the brain or spinal cord, characterized by the activation of microglia, release of pro-inflammatory cytokines, and potential synaptic degradation.

Mentioned In

DHA Target Engagement & Cognition in Dementia Risk BIOLOGICAL CIRCUITS Exerkine Blood-Brain Barrier Signaling BIOLOGICAL CIRCUITS Fasting, Microbiome Shifts, and Neuroinflammation BIOLOGICAL CIRCUITS Gut Dysbiosis & Microglial Priming in Alzheimer's BIOLOGICAL CIRCUITS microglia ORGANISM

Scientific Sources & Verbatim Definitions

Empirical StudyMela V, et al. Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis. Gut. 2025;74:1828-1846. ↗ (Page 1829)
"Chronic neuroinflammation, mediated by activated microglia, is a major driver of cognitive decline and synaptic loss in obesity."