neuroinflammation
Type: process Aliases: brain inflammationinflammatory cascades in the brainneuroinflammation markers
- Systems Analogy A fire alarm stuck on high volume that starts damaging the building it's trying to protect.
- Formal Definition An inflammatory response within the brain or spinal cord, characterized by the activation of microglia, release of pro-inflammatory cytokines, and potential synaptic degradation.
Mentioned In
- Biological CircuitsDHA Target Engagement & Cognition in Dementia Risk, Exerkine Blood-Brain Barrier Signaling, Fasting, Microbiome Shifts, and Neuroinflammation, Gut Dysbiosis & Microglial Priming in Alzheimer's, Periodontal Pathology and Alzheimer's Link
- Organismmicroglia
- ProcessAlternate Day Fasting
Scientific Sources & Literature Citations
- [1] Empirical Study Mela V, et al. Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis. Gut. 2025;74:1828-1846. ↗
"Chronic neuroinflammation, mediated by activated microglia, is a major driver of cognitive decline and synaptic loss in obesity."