amyloid-beta
Type: protein Aliases: amyloid plaques beta-amyloid Aβ
Systems Analogy
A build-up of industrial dust and slag in the exhaust channels that can clog system ventilation and trigger localized overheating.
A protein peptide that can accumulate in the brain, forming sticky plaques associated with neurodegeneration and Alzheimer's disease progression.
Mentioned In
Scientific Sources & Verbatim Definitions
- Empirical StudySelkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016;8(6):595-608. ↗
"The accumulation of amyloid-beta peptides in the cerebral cortex is a critical early event in the pathogenesis of Alzheimer's disease."