atuzaginstat
Type: molecule Aliases: COR388
Systems Analogy
A custom-fitted safety cap that locks onto bacterial shears, neutralizing their ability to cut structural cables.
COR388; an experimental, brain-penetrant small-molecule inhibitor of Porphyromonas gingivalis Lys-gingipains, developed to block neurodegeneration in Alzheimer's.
Scientific Sources & Verbatim Definitions
- Empirical StudyClinicalTrials.gov study. GAIN Trial: Phase 2/3 study of atuzaginstat in mild-to-moderate Alzheimer's disease. NCT03823404. ↗
"Atuzaginstat selectively inhibits gingipain-induced toxicity to protect neural structures."