atuzaginstat
Type: molecule Aliases: COR388
- Systems Analogy An experimental medicine designed to block toxic bacterial enzymes and protect brain tissue.
- Formal Definition COR388; an experimental, brain-penetrant small-molecule inhibitor of Porphyromonas gingivalis Lys-gingipains, developed to block neurodegeneration in Alzheimer's.
Mentioned In
- Moleculegingipains
Scientific Sources & Literature Citations
- [1] Empirical Study ClinicalTrials.gov study. GAIN Trial: Phase 2/3 study of atuzaginstat in mild-to-moderate Alzheimer's disease. NCT03823404. ↗
"Atuzaginstat selectively inhibits gingipain-induced toxicity to protect neural structures."