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blood-brain barrier

Aliases: BBBblood-brain barrier integrityblood-brain barrier transport

Systems Analogy A strict security checkpoint protecting the brain, letting nutrients in while blocking toxins.
Formal Definition A highly selective semipermeable membrane border of endothelial cells that prevents solutes in the circulating blood from non-selectively crossing into the extracellular fluid of the central nervous system.

Mentioned In

Biological CircuitsDHA Target Engagement & Cognition in Dementia Risk, Exerkine Blood-Brain Barrier Signaling, Gut Dysbiosis & Microglial Priming in Alzheimer's, Periodontal Pathology and Alzheimer's Link
MoleculeDHA, homocysteine
ProteinAPOE4

Scientific Sources & Literature Citations

[1] Empirical Study Yassine HN, et al. CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia. eBioMedicine. 2026;106:106316. ↗ (Page Introduction)
"The blood-brain barrier regulates chemical transport to ensure optimal CNS homeostasis."