gut-brain axis
Type: process Aliases: gut-brain gut-microglia axis gut-brain pathway gut-brain axis communication
Systems Analogy
A two-way express shipping highway linking a rural agricultural hub directly with city hall.
The bidirectional biochemical communication network linking the gastrointestinal tract and its resident microbiota with the central nervous system.
Mentioned In
Scientific Sources & Verbatim Definitions
- Empirical StudyMela V, et al. Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis. Gut. 2025;74:1828-1846. ↗
"These results establish the gut-brain axis as a key pathway through which diet-induced microbiome shifts modulate microglia."