misfolded proteins
Type: molecule Aliases: misfoldedprotein misfoldingmisfolding
- Systems Analogy Twisted or misshapen puzzle pieces that cannot do their job and clutter up the cell.
- Formal Definition Proteins that have failed to fold into their correct 3D shape, rendering them non-functional and prone to aggregating into toxic clumps that disrupt cell viability.
Mentioned In
- Processautophagy
Scientific Sources & Literature Citations
- [1] Empirical Study Dobson CM. Protein folding and misfolding. Nature. 2003;426(6968):884-890. ↗
"Misfolded proteins aggregate to form cytotoxic deposits."