misfolded proteins
Type: molecule Aliases: misfolded protein misfolding misfolding
Systems Analogy
Warped or bent machine parts that fail to fit and jam the conveyor belt, causing system halts.
Proteins that have failed to fold into their correct 3D shape, rendering them non-functional and prone to aggregating into toxic clumps that disrupt cell viability.
Mentioned In
Scientific Sources & Verbatim Definitions
- Empirical StudyDobson CM. Protein folding and misfolding. Nature. 2003;426(6968):884-890. ↗
"Misfolded proteins aggregate to form cytotoxic deposits."