oxidative stress
Type: process Aliases: oxidative damageoxidative stress pathwaysoxidative degradation
- Systems Analogy Cellular wear and tear caused by an overload of reactive chemicals damaging cell parts.
- Formal Definition An imbalance between the production of reactive oxygen species (ROS) and cellular antioxidant defenses, leading to DNA damage and lipid peroxidation.
Mentioned In
- Biological CircuitsCerebrovascular DHA Peroxidation & Membrane Stability, DHA Target Engagement & Cognition in Dementia Risk, Dietary Cadmium Nephrotoxicity via Metal Mimicry
- Conceptcytoprotective
- Moleculeantioxidant, EGCG, free radicals, reactive oxygen species
- Processdetoxification, lipid peroxidation
- ProteinNrf2
Scientific Sources & Literature Citations
- [1] Empirical Study Ma Q. Role of Nrf2 in Oxidative Stress and Toxicity. Annu Rev Pharmacol Toxicol. 2013;53:401-426. ↗
"Oxidative stress damages macromolecules and alters cellular signaling dynamics."