Nrf2
Type: protein Aliases: nuclear factor erythroid 2-related factor 2
- Systems Analogy A master smoke alarm switch that turns on all the body natural defense shields against stress.
- Formal Definition Nuclear factor erythroid 2-related factor 2; a Nuclear factor that coordinates the gene expression of cytoprotective, antioxidant, and phase II detoxification enzymes.
Mentioned In
- Biological CircuitsPhytochemical Regulation of Aging Pathways
- Conceptcytoprotective
- Moleculeantioxidant, free radicals, reactive oxygen species, sulforaphane
- Processdetoxification, oxidative stress
Scientific Sources & Literature Citations
- [1] Empirical Study Ma Q. Role of Nrf2 in Oxidative Stress and Toxicity. Annu Rev Pharmacol Toxicol. 2013;53:401-426. ↗
"Nrf2 coordinates transcription profiles for a large battery of cytoprotective genes."