Porphyromonas gingivalis
Type: organism Aliases: P. gingivalisperiodontal pathogen
- Systems Analogy A harmful mouth bacterium from infected gums that can travel through the bloodstream.
- Formal Definition A gram-negative, anaerobic oral pathogen and keystone species in chronic periodontitis, linked to systemic inflammation and postmortem brain pathology.
Mentioned In
- Biological CircuitsPeriodontal Pathology and Alzheimer's Link
- Conceptpathogenicity
- Conditiondysbiotic oral plaque, gut dysbiosis, periodontitis
- Moleculeatuzaginstat, gingipains
- Processalveolar bone resorption
Scientific Sources & Literature Citations
- [1] Empirical Study Dominy SS, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. ↗
"Porphyromonas gingivalis is identified as a primary pathogen linking periodontitis to Alzheimer's pathology."