Porphyromonas gingivalis

Aliases: P. gingivalis periodontal pathogen

Systems Analogy

Invasive pests nesting in peripheral water mains (the gums) and traveling upstream into the city's central water reservoir (the brain).

A gram-negative, anaerobic oral pathogen and keystone species in chronic periodontitis, linked to systemic inflammation and postmortem brain pathology.

Mentioned In

Periodontal Pathology and Alzheimer's Link BIOLOGICAL CIRCUITS atuzaginstat MOLECULE dysbiotic oral plaque CONDITION gingipains MOLECULE

Scientific Sources & Verbatim Definitions

Empirical StudyDominy SS, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. ↗ (Page 1)
"Porphyromonas gingivalis is identified as a primary pathogen linking periodontitis to Alzheimer's pathology."