LPS
Type: molecule Aliases: lipopolysaccharideendotoxin
- Systems Analogy Irritating bacterial wall fragments leaking into the bloodstream that trigger inflammatory fire alarms.
- Formal Definition Lipopolysaccharide; a major component of the outer membrane of Gram-negative bacteria that acts as a potent endotoxin, inducing microglial activation and systemic inflammatory cascades.
Mentioned In
- Biological CircuitsGut Dysbiosis & Microglial Priming in Alzheimer's
- ProteinTLR4
Scientific Sources & Literature Citations
- [1] Empirical Study Zhan X, et al. Gram-negative bacterial molecules associate with Alzheimer disease pathology. Neurology. 2016;87(22):2324-2332. ↗
"Lipopolysaccharide (LPS) is a component of Gram-negative bacterial outer membrane that acts as an endotoxin to induce microglial activation."